An autoimmune disease variant of IgG1 modulates B cell activation and differentiation

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07/10/2018

⏱ 1 min read

The maintenance of autoreactive B cells in a quiescent state is crucial for preventing autoimmunity. Here, we identify a variant of human IgG1 (hIgG1-G396R), which positively correlates with systemic lupus erythematosus. In induced lupus models, murine homolog G390R knock-in mice generate excessive numbers of plasma cells, leading to a burst of broad-spectrum autoantibodies. This enhanced production of antibodies is also observed in hapten-immunized G390R mice, as well as in influenza-vaccinated human G396R homozygous carriers. This variant potentiates the phosphorylation of IgG1 immunoglobulin tail tyrosine (ITT) motif. This, in turn, alters the availability of phospho-ITT to trigger lon…
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Pavlos Papadopoulos

Pavlos Papadopoulos is a Senior Field Engineer and long-time technology enthusiast based in Thessaloniki, Greece. With over a decade of hands-on experience working with hardware, software, mobile devices, and real-world IT systems, he brings a practical, engineer-level perspective to every article he writes.A passionate smartphone user—especially within the Xiaomi ecosystem—Pavlos explores how apps, tools, and everyday technologies perform in real use. His interests span programming, web development, DIY tech projects, digital workflows, and productivity tools.He is also the founder and editor of three technology websites: Gadget Rumours, TheLatestTechNews, and TechnologyNews.info, where he has written and curated more than a thousand articles covering software, mobile tech, hardware, and emerging digital trends.Pavlos is committed to clear explanations, helpful guides, and honest, experience-based insights that help readers make better decisions about the technology they use every day.

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