Home Technology News Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors

Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors

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Neuromodulatory systems exert profound influences on brain function. Understanding how these systems modify the operating mode of target circuits requires measuring spatiotemporally precise neuromodulator release. We developed dLight1, an intensity-based genetically encoded dopamine indicator, to enable optical recording of dopamine dynamics with high spatiotemporal resolution in behaving mice. We demonstrated the utility of dLight1 by imaging dopamine dynamics simultaneously with pharmacolog…
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