Structural basis for the modulation of voltage-gated sodium channels by animal toxins

Animal toxins that modulate the activity of Nav channels are broadly divided into two categories—pore blockers and gating modifiers. The pore blockers tetrodotoxin (TTX) and saxitoxin (STX) are responsible for pufferfish and shellfish poisoning in humans, respectively. Here we present structures of the insect Nav channel NavPaS bound to a gating modifier toxin Dc1a at 2.8 Å and in the presence of TTX or STX at 2.6 Å and 3.2 Å resolution…
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