Co-regulatory networks of human serum proteins link genetics to disease

Proteins circulating in the blood are critical for age-related disease processes, however the serum proteome has remained largely unexplored. To this end, 4,137 proteins covering most predicted extracellular proteins, were measured in the serum of 5,457 Icelanders over 65 years of age. Pair-wise correlation between proteins as they varied across individuals, revealed 27 different network modules of serum proteins, many of which were associated with cardiovascular and metabolic disease states …
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