A molecular mechanism for Wnt ligand-specific signaling

Wnt signaling is key to many developmental, physiological and disease processes, in which cells seem able to discriminate between multiple Wnt ligands. This selective Wnt recognition or “decoding” capacity has remained enigmatic as Wnt/Frizzled interactions are largely incompatible with mono-specific recognition. Gpr124 and Reck enable brain endothelial cells to selectively respond to Wnt7. We show that Reck binds with low micromolar affinity to the intrinsically disordered linker region of W…
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